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Inflammatory Bowel Disease During Childhood ... A new study revealed an increased risk of cancer and early death ... (13 May 2019)
Fracture Risk Tool Is Useful in Women with ... The FRAX®tool takes into account certain factors to determine ... (13 May 2019)
Antibiotic cocktail stops cancer cells from ... Scientists in Salford, UK have found a way to make cancer stem ... (13 May 2019)
Statins Linked to Lower Risk of Early Death ... Use of statins before or after a diagnosis of colorectal cancer ... (13 May 2019)
Do Sunscreen Compromises Vitamin D Levels? Sunscreen can reduce the sun’s adverse effects, but there are ... (13 May 2019)
Wednesday, 15 May 2019 09:31

Doctors Wanted - Pasteur Pharmacy

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Doctors Wanted - Pasteur Pharmacy!  Join a successful team with over 25 years of experience.

Tuesday, 14 May 2019 15:39

Job Vacancies at Saint James Hospital

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Saint James Hospital Group is seeking to employ Medical Officers to join our Resident Medical Officer Teams in Sliema and Tarxien, on a Full Time and a Part Time basis....

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A new study revealed an increased risk of cancer and early death in individuals who developed inflammatory bowel disease–including ulcerative colitis (UC) and Crohn’s disease (CD)—during childhood.

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The FRAX®tool takes into account certain factors to determine the risk of bone fracture in the general population.

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Use of statins before or after a diagnosis of colorectal cancer was linked with a lower risk of premature death, both from cancer and from other causes, in a Cancer Medicine analysis of published studies.

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Scientists in Salford, UK have found a way to make cancer stem cells reproduce defectively “like cars without engines”.

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Sunscreen can reduce the sun’s adverse effects, but there are concerns that it might inhibit the body’s production of vitamin D.

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The short-term supplementation of monacolin K improves the lipid and metabolic patterns of hypertensive and hypercholesterolemic subjects at low cardiovascular risk.

Background - The clinical hypocholesterolemic effect of nutraceutical compounds (NCs) containing red yeast rice extracts providing a daily dose of 2.5-10 mg of monacolin K is now well established. For this reason, NCs may be a viable alternative to the statin drugs commonly used to lower cholesterol levels. However, in order to avoid some possible statin-like side effects, most NCs available on the market contain low doses of monacolin K, which could reduce their efficacy. The aim of this study was to investigate the efficacy and safety of a NC containing high doses of monacolin K (10 mg) in improving the lipid profile and glucose metabolism when added to the diet versus the diet alone in a group of hypertensive and hyper-cholesterolemic subjects at low cardiovascular risk. Methods - Thirty subjects with grade-1 essential hypertension (mean age 51.5 ± 7.8 years, 62.9% males) were enrolled in the treatment group (NC group). These subjects followed a programmed diet and took one tablet a day of a NC containing red yeast rice, policosanols, resveratrol and chromium picolinate for 1 month and were compared with an equivalent group of subjects that followed only a diet program. Differences in serum total cholesterol (TC), low-density- and high-density-lipoprotein cholesterol (LDLC and HDLC), triglycerides (TG) and blood glucose between groups were compared by analysis of variance. Results - In both groups, a significant reduction of TC, TG and LDLC was observed. In the treatment group from the baseline to the follow-up the reduction of TC (230.93 ± 28.0 vs. 188.63 ± 18.1, p < 0.001) and LDLC (153.10 ± 22.5 vs. 116.54 ± 17.7, p < 0.001) was significantly greater compared to the control group (differences between treatments = 9.19% and 12.29%, respectively); in addition a significant higher reduction in blood glucose (89.1 ± 7.6 vs. 83.7 ± 4.6, p < 0.001) was also observed (differences between treatments = 4.28%). HDLC levels remained unchanged in both groups. Conclusions - In summary, the NC containing high doses of monacolin K appeared to be safe, well tolerated and effective at improving lipid and glucose patterns.

 

Reference: Food Funct. 2018 Jul 17;9(7):3845-3852.

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Artificial intelligence (AI) has shown promise to select heart failure patients for expensive treatments to prevent lethal arrhythmias, reports a study presented at ICNC 2019.1 The study is the first to use a machine learning algorithm to predict sudden death in heart failure patients.

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Cognitive frailty is a heterogeneous clinical manifestation characterized by the simultaneous presence of both physical frailty and cognitive impairment, in the absence of dementia, and it seems to entail a greater death risk than physical frailty or cognitive impairment separately.

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