This website is intended for Medical Professionals only. By using this site you confirm that you are a healthcare professional.

News
Recurrent miscarriage: diabetes drug could ... An existing drug can be used to improve the womb for pregnancy, ... (08 Jan 2020)
Nerve Stimulation May Benefit Women with ... A treatment involving electrical nerve stimulation helped women ... (08 Jan 2020)
Cancer drugs could potentially treat COPD, ... New research from the University of Sheffield shows a certain ... (08 Jan 2020)
Tea drinkers live longer Drinking tea at least three times a week is linked with a longer ... (08 Jan 2020)

“Fresher” Blood Donations May Be Better for Recipients

Although clinical evidence is lacking on the relationship between the storage time of red blood cells and outcomes in transfused patients, the authors of a review article in the November 2013 issue of The Annals of Thoracic Surgery are advocating for a modernized blood management system—similar to inventory management systems seen in the retail sector—to potentially reduce patient complications.

 

Duration of storage is dependent on a number of factors, including the management system, supply and demand, and blood type (less common blood types, such as Type AB negative, tend to be stored longer than more common types, particularly Type O). Currently, the Food and Drug Administration (FDA) limits storage duration to a maximum of 42 days, depending on the storage system.

“Stored blood undergoes changes, meaning that transfusion of older red blood cells may result in the delivery of high concentrations of red blood cell components such as hemoglobin, free iron, and red blood cell fragments,” said Colleen G. Koch, MD, MS, MBA, from the Cleveland Clinic in Ohio. “These components may contribute to adverse clinical events observed in a number of investigations.”

Dr. Koch and colleagues reviewed existing literature to examine the presence of storage-related complications in patients who underwent blood transfusions. They found several studies in trauma and cardiac surgery that linked increased blood storage duration to post-injury multiple organ failure, infection, deep vein thrombosis, and hospital mortality, while other studies reported no apparent relationship between storage duration and clinical outcomes.

Several ongoing randomized controlled trials may answer more questions in the future. Meanwhile, the researchers recommend exploring changes to the current first-in, first-out process. They pointed to new models of inventory management in the retail sector that would reduce inventory shelf time in favor of just-in-time delivery of products.

“We hope our results engage others in the medical community to investigate alternative inventory management strategies that would contribute to reducing the storage age of the red cell product without adversely influencing inventory availability,” said Dr. Koch.

One existing model involves blood platelet donation. Platelets expire 5 days after donation, so managing platelet inventory requires hourly monitoring and more frequent deliveries from blood collection agencies. Using these same techniques for red blood cell donations could help reduce blood storage duration to 14 days or less, according to the researchers.

“We recommend further work with inventory management to explore strategies that would optimize fresher blood for patients,” said Dr. Koch. “Until results of ongoing randomized controlled trials in the area of storage duration are completed, we cannot recommend a change in the current FDA formal guidelines; however, we encourage surgeons to remain aware of the possible complications associated with red blood cell transfusion.”

 


 

Source Newsroom: Society of Thoracic Surgeons

Highlights

  • Nescafé 3 in1 LifeCycle HEROES return from South Asia

    Donations for Nescafé 3in1 LifeCycle Challenge 2019 can be sent via sms: 5061 7370 = €2.33; 5061 8920 = €6.99; 5061 9229 = €11.65; or via a call to 5160 2020 = €10, 5170 2005 = €15; and 5180 2006 = €25. Bank details are Swift code VALLMTMT, IBAN number MT 18 VALL 22013000000014814521017, Bank name Bank of Valletta, Account number 14814521017.

    Read more...
  • Give a Gift this Christmas which gives back

    The story of medicine is the story of civilization, from an ancient craft of primitive magic and religion to the sophisticated field of science and technology of today.

    Read more...

Join

Connect with other Medical Professionals on fb in a closed facebook group

Login

Top
We use cookies to improve our website. By continuing to use this website, you are giving consent to cookies being used. More details…