This website is intended for Medical Professionals only. By using this site you confirm that you are a healthcare professional.

News
Recurrent miscarriage: diabetes drug could ... An existing drug can be used to improve the womb for pregnancy, ... (08 Jan 2020)
Nerve Stimulation May Benefit Women with ... A treatment involving electrical nerve stimulation helped women ... (08 Jan 2020)
Cancer drugs could potentially treat COPD, ... New research from the University of Sheffield shows a certain ... (08 Jan 2020)
Tea drinkers live longer Drinking tea at least three times a week is linked with a longer ... (08 Jan 2020)

Colonoscopy Screening Reduces Risk of Advanced Colorectal Cancer

A new study led by a researcher at the Perelman School of Medicine at the University of Pennsylvania adds support to current medical recommendations stating that screening colonoscopy substantially reduces an average-risk adult’s likelihood of being diagnosed with advanced colorectal cancer (CRC) in either the right or left side of the colon.

In recent years, colonoscopy has begun to rapidly replace sigmoidoscopy – a procedure used to detect abnormalities in the rectum and left side of the colon – despite initially limited evidence of its efficacy and higher cost. In the new study, researchers noted an overall 70 percent reduction of advanced CRC diagnoses associated with receiving a screening colonoscopy. The results of the study suggest that colonoscopy has the ability to effectively identify tumors in both the left and right side of the colon before they progress to an advanced stage. The full results of the study appear online in the Annals of Internal Medicine.

Previous research has established that screening with sigmoidoscopy or fecal occult blood test reduces the risk of death from colorectal cancer. By contrast, the efficacy of the colonoscopy – which examines the entire colon for precancerous and cancerous growths – in average-risk adults has remained largely uncertain. Colonoscopy’s effectiveness in the right colon (where approximately 50 percent of new CRC cases are found) has remained in doubt.

“Colorectal cancer is one of the most important cancers. In the US, it was responsible for over 50,000 deaths in 2012, and the truth is, most of those deaths are preventable through screening, early detection, and treatment,” said Chyke Doubeni, associate professor of Family Medicine and Community Health at Penn Medicine, and lead author on the study. “Our goal with this study was to understand the extent to which colonoscopy can prevent the diagnosis of advanced colorectal cancers, the ones that primarily result in death. What we saw was a dramatically reduced risk of death for patients who were screened.”

Although the incidence of CRC and cancer-related deaths is decreasing, CRC remains the third most common cancer worldwide and the second leading cause of cancer deaths. Experts say that given what is known about the efficacy of screening colonoscopy, the procedure is underutilized.

“Screening colonoscopy is used to look for early growths which may turn into cancer by allowing physicians to see any polyps or bleeding in the colon or rectum,” explains Michael Kochman, MD, Wilmott Family Professor of Medicine and co-director of the Gastrointestinal Oncology Program at Penn Medicine. “If any abnormalities – such as polyps – are detected, the physician can remove all or part of them with biopsy techniques during the procedure, making it a very effective means of spotting and removing potentially cancerous growths.”

In order to determine the efficacy of colonoscopy in preventing advanced colorectal cancer diagnoses, the researchers developed a case-control study in which data from four U.S. managed care organizations that participate in the HMO Cancer Research Network were evaluated. Medical records for 1,012 average-risk patients between 55-85 years old were analyzed for the report. Among the 474 patients in the study who had advanced colorectal cancer, 251 of them (roughly 54 percent) had tumors in the right side of the colon – where sigmoidoscopy would not have been an effective screening modality. Randomized trials are currently underway to help researchers learn more about the effectiveness of colonoscopy, but those results will not be available for several years.

“The results of this study confirm the effectiveness of screening colonoscopy and reinforce the importance of the procedure for all adults over the age of 50,” said Robert H. Fletcher, MD, MSc, professor emeritus at Harvard Medical School and co-author on the study. “As we wait to learn more about the effectiveness of screening colonoscopy through clinical trials, this case-control study provides credible answers that support current screening practices and recommendations.”


 

Source Newsroom: Perelman School of Medicine at the University of Pennsylvania

Highlights

  • Nescafé 3 in1 LifeCycle HEROES return from South Asia

    Donations for Nescafé 3in1 LifeCycle Challenge 2019 can be sent via sms: 5061 7370 = €2.33; 5061 8920 = €6.99; 5061 9229 = €11.65; or via a call to 5160 2020 = €10, 5170 2005 = €15; and 5180 2006 = €25. Bank details are Swift code VALLMTMT, IBAN number MT 18 VALL 22013000000014814521017, Bank name Bank of Valletta, Account number 14814521017.

    Read more...
  • Give a Gift this Christmas which gives back

    The story of medicine is the story of civilization, from an ancient craft of primitive magic and religion to the sophisticated field of science and technology of today.

    Read more...

Join

Connect with other Medical Professionals on fb in a closed facebook group

Login

Top
We use cookies to improve our website. By continuing to use this website, you are giving consent to cookies being used. More details…