This website is intended for Medical Professionals only. By using this site you confirm that you are a healthcare professional.

News
Recurrent miscarriage: diabetes drug could ... An existing drug can be used to improve the womb for pregnancy, ... (08 Jan 2020)
Nerve Stimulation May Benefit Women with ... A treatment involving electrical nerve stimulation helped women ... (08 Jan 2020)
Cancer drugs could potentially treat COPD, ... New research from the University of Sheffield shows a certain ... (08 Jan 2020)
Tea drinkers live longer Drinking tea at least three times a week is linked with a longer ... (08 Jan 2020)

Association of physical activity with diabetes is weakest among women at high genetic risk

New research published in Diabetologia suggests that the protective effect of physical activity against diabetes is weakest among those at high genetic risk. The research is by Dr Yann Klimentidis, an Assistant Professor at the University of Arizona Mel and Enid Zuckerman College of Public Health, in Tucson, AZ, USA, and colleagues.
It is well established that physical activity reduces type 2 diabetes risk. However, the extent of protection afforded by physical activity may differ according to genetic factors. In this study, the authors examined the interaction of 65 type 2 diabetes-associated genetic variants (single nucleotide polymorphisms/SNPs), collectively and individually, with each individual’s baseline level of physical activity on incident type 2 diabetes in a prospective cohort study.
The authors used data on 8,101 self-identified white participants in the Atherosclerosis Risk in Communities study (ARIC). The ARIC study is a multi-center prospective study of atherosclerosis in men and women between 45 and 64 years of age. Within this cohort, there were 821 incident type 2 diabetes cases. The researchers studied interactions of physical activity with 1) each of 65 type 2 diabetes-associated SNPs, 2) a genetic risk score (GRS) comprised of all 65 SNPs, 3) two GRSs comprised of SNPs implicated in insulin resistance and insulin secretion, and 4) GRSs for fasting insulin and glucose.
Each individual’s level of physical activity was assessed through the Baecke Physical Activity questionnaire, a standard assessment tool. The researchers focused on the sport and exercise components of physical activity.
The researchers found a significant interaction of physical activity and the type 2 diabetes GRS, suggesting a weaker protective effect of physical activity in those at high genetic risk. Based on the interactions observed with the insulin resistance GRS and the fasting insulin GRS, it appears that the overall type 2 diabetes GRS interaction most likely occurs through genetic susceptibility to insulin resistance, as opposed to insulin secretion. Furthermore, this interaction was more pronounced in women than in men. No single SNP stood out as displaying a strong interaction with physical activity.
The researchers say: “We conclude that although physical activity appears to have an overall protective effect on type 2 diabetes, this putative effect is weakest among individuals with high genetic risk for type 2 diabetes and insulin resistance.”

Highlights

  • Give a Gift this Christmas which gives back

    The story of medicine is the story of civilization, from an ancient craft of primitive magic and religion to the sophisticated field of science and technology of today.

    Read more...
  • Nescafé 3 in1 LifeCycle HEROES return from South Asia

    Donations for Nescafé 3in1 LifeCycle Challenge 2019 can be sent via sms: 5061 7370 = €2.33; 5061 8920 = €6.99; 5061 9229 = €11.65; or via a call to 5160 2020 = €10, 5170 2005 = €15; and 5180 2006 = €25. Bank details are Swift code VALLMTMT, IBAN number MT 18 VALL 22013000000014814521017, Bank name Bank of Valletta, Account number 14814521017.

    Read more...

Join

Connect with other Medical Professionals on fb in a closed facebook group

Login

Top
We use cookies to improve our website. By continuing to use this website, you are giving consent to cookies being used. More details…