The trial included adults between 18 and 65 years of age with confirmed influenza infections who were treated with the maximum recommended dose of paracetamol or placebo for five days. Participants were monitored for up to 14 days.
"We initially theorized that taking paracetamol might be harmful, as the influenza virus cannot replicate as well at higher temperatures, and by reducing a person's temperature the virus may have thrived. Fortunately this was found not be the case," said Dr. Irene Braithwaite, co-author of the Respirology study. "In this study, paracetamol was not harmful, but we also found that paracetamol was not beneficial either."
Dr. Braithwaited noted that it is difficult to make a recommendation for or against the use of paracetamol in adults with influenza or influenza-like illness based on these results. "One of the things we need to take from this, though, is that those at risk-particularly pregnant women, the very young, the old, and those with chronic medical conditions-should have the annual influenza vaccination as it confers the best protection available against the influenza virus."
Full bibliographic information:
"Randomized controlled trial of the effect of regular paracetamol on influenza infection"
Sarah Jefferies, Irene Braithwaite, Steven Walker, Mark Weatherall, Lance Jennings, Michelle Luck, Kevin Barrett, Robert Siebers, Timothy Blackmore, Richard Beasley, Kyle Perrin andOn behalf of thePi Study Group, Respirology.