This website is intended for Medical Professionals only. By using this site you confirm that you are a healthcare professional.

News
Recurrent miscarriage: diabetes drug could ... An existing drug can be used to improve the womb for pregnancy, ... (08 Jan 2020)
Nerve Stimulation May Benefit Women with ... A treatment involving electrical nerve stimulation helped women ... (08 Jan 2020)
Cancer drugs could potentially treat COPD, ... New research from the University of Sheffield shows a certain ... (08 Jan 2020)
Tea drinkers live longer Drinking tea at least three times a week is linked with a longer ... (08 Jan 2020)

Not the Weaker Sex: Estrogen Protects Women Against the Flu, Study Finds

  • Not the Weaker Sex: Estrogen Protects Women against the Flu, Study Finds
  • Study in human cells supports why the flu may hit men harder than women

flu coupleThe female sex hormone estrogen has anti-viral effects against the influenza A virus, commonly known as the flu, a new study in American Journal of Physiology—Lung Cellular and Molecular Physiology reports.
A virus infects and causes sickness by entering a cell and making copies of itself inside the host cell. When released from infected cells, the virus can spread through the body and between people. How much a virus has replicated determines its severity. Less replication of the virus means the infected person may experience less disease or is less likely to spread the disease to someone else, says Sabra Klein, PhD, of Johns Hopkins University and lead investigator of the study.
To examine how estrogen affected the flu virus’s ability to replicate, the research team gathered nasal cells—the cell type that the flu virus primarily infects—from male and female donors. The researchers exposed the cell cultures to the virus, estrogen, the environmental estrogen bisphenol A and selective estrogen receptor modulators (SERM), which are compounds that act like estrogen that are used for hormone therapy.
The researchers found that estrogen, SERM compound raloxifene and bisphenol A reduced flu virus replication in nasal cells from women but not men. They also observed that the estrogens initiated their antiviral effects through estrogen receptor beta. Receptors are protein structures that molecules bind with to induce cells to respond.
According to Klein, “Other studies have shown that estrogens have antiviral properties against HIV, Ebola and hepatitis viruses. What makes our study unique is two-fold. First, we conducted our study using primary cells directly isolated from patients, allowing us to directly identify the sex-specific effect of estrogens. Second, this is the first study to identify the estrogen receptor responsible for the antiviral effects of estrogens, bringing us closer to understanding the mechanisms mediating this conserved antiviral effect of estrogens.”
The findings in this new study support earlier evidence from studies in animals that showed protective effects of estrogen against the flu. “Because estrogen levels cycle in premenopausal women, it may be difficult to see this protective effect in the general population,” Klein notes. “But, premenopausal women on certain kinds of birth control or post-menopausal women on hormone replacement may be better protected during seasonal influenza epidemics,” she says. “We see clinical potential in the finding that therapeutic estrogens that are used for treating infertility and menopause may also protect against the flu.”
The article “Estrogenic compounds reduce influenza A virus replication in primary human nasal epithelial cells derived from female, but not male, donors” is published ahead-of-print in the American Journal of Physiology—Lung Cellular and Molecular Physiology.


Source Newsroom: American Physiological Society

Highlights

  • Nescafé 3 in1 LifeCycle HEROES return from South Asia

    Donations for Nescafé 3in1 LifeCycle Challenge 2019 can be sent via sms: 5061 7370 = €2.33; 5061 8920 = €6.99; 5061 9229 = €11.65; or via a call to 5160 2020 = €10, 5170 2005 = €15; and 5180 2006 = €25. Bank details are Swift code VALLMTMT, IBAN number MT 18 VALL 22013000000014814521017, Bank name Bank of Valletta, Account number 14814521017.

    Read more...
  • Give a Gift this Christmas which gives back

    The story of medicine is the story of civilization, from an ancient craft of primitive magic and religion to the sophisticated field of science and technology of today.

    Read more...

Join

Connect with other Medical Professionals on fb in a closed facebook group

Login

Top
We use cookies to improve our website. By continuing to use this website, you are giving consent to cookies being used. More details…