A new systematic review of randomized clinical trials lasting 12 to 52 weeks found that when added to metformin, gliclazide confers the lowest risk of hypoglycemia compared with glipizide, glimepiride, and glibenclamide.
"Risk of hypoglycemia with the SU agents makes the newer and more expensive antidiabetics preferable when metformin monotherapy fails. However, our data indicate that the risk of hypoglycemia differs between the SU agents," said Dr. Stig Ejdrup Andersen, co-author of the British Journal of Clinical Pharmacology analysis. "Thus, prescribing an SU with low risk of hypoglycemia might still be a rational and affordable alternative to many patients with type 2 diabetes."
Full bibliographic information:
Andersen S E and Christensen M. Hypoglycaemia when Adding Sulphonylurea to Metformin: A Systematic Review and Network Meta-analysis. British Journal of Clinical Pharmacology.