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Study questions benefits of testosterone replacement for low testosterone

testosteroneThe prescription of testosterone supplementation for cardiovascular health, sexual function, physical function, mood, or cognitive function in men with “low T” is not supported by clinical trials data, conclude researchers who describe a review of more than 200 clinical trials published in PLOS One.
“Testosterone has been marketed to improve a number of conditions but for the vast majority, our review of the data shows that not one of these claims has adequate clinical trial support,” says Adriane Fugh-Berman, MD, a pharmaceutical marketing expert at Georgetown University Medical Center.
Fugh-Berman and her colleagues conducted a review of 226 eligible randomized controlled trials conducted between 1950 and 2016 in which testosterone was compared to placebo for cardiovascular health, sexual function, physical function, mood, or cognitive function. (Studies involving bodybuilding, contraceptive effectiveness, or treatment of any condition in women or children were excluded).

The researchers concluded:
• Testosterone supplement “did not show consistent benefit for cardiovascular risk, sexual function, mood and behavior, or cognition;”
• Improvement is seen in some surrogate markers of cardiovascular risk, but there is “little evidence” of clinical benefit;
• Studies that examined clinical cardiovascular endpoints “have not favored testosterone therapy over placebo;”
• Testosterone is “ineffective” in treating erectile dysfunction and “did not show a consistent effect on libido;”
• Testosterone supplementation consistently increased muscle strength but “did not have beneficial effects on physical function;” and
• “Most studies on mood-related endpoints found no beneficial effect of testosterone treatment on personality, psychological well-being, or mood.”

“Testosterone products are marketed for non-specific symptoms associated with normal aging, but testosterone is not a reasonable treatment for aging,” says Fugh-Berman. “Testosterone has known risks and no clear benefits, and shouldn't be used by men with intact testicles.”



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